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Publication selection 2012 - 2015

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Published on 15 January 2016

​​2015

Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition
Roy M, Cardoso C, Dorieux O, Malgorn C, Epelbaum S, Petit F, Kraska A, Brouillet E, Delatour B, Perret M, Aujard F, Dhenain M
Neurobiol. Aging

Automatic segmentation of the striatum and globus pallidus using MIST: Multimodal Image Segmentation Tool.
Visser E, Keuken M C, Douaud G, Gaura V, Bachoud-Levi A C, Remy P, Forstmann B U, Jenkinson M 
NeuroImage​​

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease
Djelti F, Braudeau J, Hudry E, Dhenain M, Varin J, Bieche I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P, Cartier N
Brain

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease
Francelle L, Galvan L, Gaillard MC, Guillermier M, Houitte D, Bonvento G, Petit F, Jan C, Dufour N, Hantraye P, Elalouf JM, de Chaldee M, Deglon N, Brouillet E 
Hum. Mol. Genet.

Optimized Quantification of Translocator Protein Radioligand F-18-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers
Lavisse S, Garcia-Lorenzo D, Peyronneau MA, Bodini B, Thiriez C, Kuhnast B, Comtat C, Remy P, Stankoff B, Bottlaender M
J. Nucl. Med.

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.
Rocher A B, Gubellini P, Merienne N, Boussicault L, Petit F, Gipchtein P, Jan C, Hantraye P, Brouillet E, Bonvento G
Neurobiology of Disease

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases
Ben Haim L, Ceyzeriat K, Carrillo-de Sauvage MA, Aubry F, Auregan G, Guillermier M, Ruiz M, Petit F, Houitte D, Faivre E, Vandesquille M, Aron-Badin R, Dhenain M, Deglon N, Hantraye P, Brouillet E, Bonvento G, Escartin C
J. Neurosci.

The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study
Carrillo-de Sauvage MA, Flament J, Bramoulle Y, Ben Haim L, Guillermier M, Berniard A, Auregan G, Houitte D, Brouillet E, Bonvento G, Hantraye P, Valette J, Escartin C
J. Cereb. Blood Flow Metab.

2014

Allele-Specific Silencing of Mutant Huntingtin in Rodent Brain and Human Stem Cells
Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, Deglon N
PLoS ONE

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion
Pannasch U, Freche D, Dallerac G, Ghezali G, Escartin C, Ezan P, Cohen-Salmon M, Benchenane K, Abudara V, Dufour A, Lubke JHR, Deglon N, Knott G, Holcman D, Rouach N   
Nat. Neurosci.​

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant
Saeed MQ, Dufour N, Bartholmae C, Sieranska U, Knopf M, Thierry E, Thierry S, Delelis O, Grandchamp N, Pilet H, Ravassard P, Massonneau J, Pflumio F, von Kalle C, Lachapelle F, Bemelmans AP, Schmidt M, Serguera C
Mol. Ther.-Nucl. Acids

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
Dujardin S, Begard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Auregan G, Hantraye P, Brouillet E, Buee L, Colin M
PLoS ONE

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson's Disease
Grealish S, Diguet E, Kirkeby A, Mattsson B, Heuer A, Bramoulle Y, Van Camp N, Perrier AL, Hantraye P, Bjorklund A, Parmar M
Cell Stem Cell

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions 
Boussicault L, Herard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, Brouillet E, Vega C, Bonvento G
J. Cereb. Blood Flow Metab.​

Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy
Najac C, Marchadour C, Guillermier M, Houitte D, Slavov V, Brouillet E, Hantraye P, Lebon V, Valette
NeuroImage

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial
Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugieres P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA
Lancet

Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
Sawiak SJ, Picq JL, Dhenain M       
Front. Aging Neurosci.​

2013​

19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles
Giraudeau C, Geffroy F, Meriaux S, Boumezbeur F, Robert P, Port M, Robic C, Le Bihan D, Lethimonnier F, Valette J
Angiogenesis

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin
Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Deglon N, Beal MF, Brouillet E
Hum. Mol. Genet.

Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds 
Joseph-Mathurin N, Dorieux O, Trouche SG, Boutajangout A, Kraska A, Fontes P, Verdier JM, Sigurdsson EM, Mestre-Frances N, Dhenain M
Neurobiol. Aging

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease
Nascimento-Ferreira I, Nobrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Deglon N, De Almeida LP
Brain​

Fast in vivo imaging of amyloid plaques using mu-MRI Gd-staining combined with ultrasound-induced blood-brain barrier opening
Santin MD, Debeir T, Bridal SL, Rooney T, Dhenain M
NeuroImage

High Throughput Screening for Inhibitors of REST in Neural Derivatives of Human Embryonic Stem Cells Reveals a Chemical Compound that Promotes Expression of Neuronal Genes
Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Auregan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL
Stem Cells

IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian
Badin RA, Spinnewyn B, Gaillard MC, Jan C, Malgorn C, Van Camp N, Dolle F, Guillermier M, Boulet S, Bertrand A, Savasta M, Auguet M, Brouillet E, Chabrier PE, Hantraye P Primates
PLoS ONE

Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain
Caillierez R, Begard S, Lecolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Auregan G, Winderickx J, Hantraye P, Deglon N, Buee L, Colin M
Mol. Ther.

Micro-MRI Study of Cerebral Aging: Ex Vivo Detection of Hippocampal Subfield Reorganization, Microhemorrhages and Amyloid Plaques in Mouse Lemur Primates
Bertrand A, Pasquier A, Petiet A, Wiggins C, Kraska A, Joseph-Mathurin N, Aujard F, Mestre-Frances N, Dhenain M
PLoS ONE

2012

Alteration of sensory-evoked metabolic and oscillatory activities in the olfactory bulb of GLAST-deficient mice
Martin C, Houitte D, Guillermier M, Petit F, Bonvento G, Gurden H. 
Front Neural Circuits. ​

Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments
Picq J L, Aujard F, Volk A, Dhenain M. 
Neurobiol Aging.
 

Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo.
Marchadour C, Brouillet E, Hantraye P, Lebon V, Valette J. 
J Cereb Blood Flow Metab. ​

Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo. 
Galvan L, Lepejova N, Gaillard M C, Malgorn C, Guillermier M, Houitte D, Bonvento G, Petit F, Dufour N, Hery P, Gerard M, Elalouf J M, Deglon N, Brouillet E, de Chaldee M. 
Neurobiol Aging
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High sensitivity 19F MRI of a perfluorooctyl bromide emulsion: application to a dynamic biodistribution study and oxygen tension mapping in the mouse liver and spleen. 
Giraudeau C, Djemai B, Ghaly M A, Boumezbeur F, Meriaux S, Robert P, Port M, Robic C, Le Bihan D, Lethimonnier F, Valette J. 
NMR Biomed.

In Vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin. 
Kraska A, Santin MD, Dorieux O, Joseph-Mathurin N, Bourrin E, Petit F, Jan C Chaigneau M, Hantraye P, Lestage P, Dhenain M. 
Plos One.

Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease. 
Poisnel G., Hérard A.S., El Tannir El Tayara N., Bourrin E., Volk A., Kober F., Delatour B., Delzescaux T., Debeir T., Rooney T., Benavides J., Hantraye P., Dhenain M.
Neurobiology of Aging. ​

pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study. 
Chaumeil M M, Valette J, Baligand C, Brouillet E, Hantraye P, Bloch G, Gaura V, Rialland A, Krystkowiak P, Verny C, Damier P, Remy P, Bachoud-Levi A C, Carlier P, Lebon V.
​J Cereb Blood Flow Metab

Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. 
Lavisse S, Guillermier M, Hérard AS, Petit F, Delahaye M, Van Camp N, Ben Haim L, Lebon V, Remy P, Dollé F, Delzescaux T, Bonvento G, Hantraye P, Escartin C.
J Neurosci. 

Restricted transgene expression in the brain with cell-type specific neuronal promoters. 
Delzor A, Dufour N, Petit F, Guillermier M, Houitte D, Auregan G, Brouillet E, Hantraye P, Déglon N.
Hum Gene ​Ther Methods.